Senior Scientist I, Discovery Pharmacology
Arrowhead Pharmaceuticals
$120,000 - $130,000 / year
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Description
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead is seeking a senior scientist to join our Biology Research Department. The candidate will be a key member of the Discovery Pharmacology team.
Responsibilities
- Design, execute and interpret in vitro, ex vivo and in vivo studies to facilitate drug discovery and development by way of understanding mechanisms of action
- Develop and optimize new cell-based functional assays to achieve project goals
- Support Biology and cross-functional team members in understanding various aspects of drug mechanism
- Independently read and apply relevant scientific literature to projects, troubleshoot and solve problems
- Present research findings to project teams and governance bodies and prepare technical reports
- Present research findings externally (conferences, journal publications)
- Maintain a high level of productivity in the lab and perform critical experiments
Requirements
- PharmD or PhD degree in immunology, cell biology, molecular toxicology, pharmaceutical sciences or pharmacology.
- 2+ years of pharmaceutical industry or relevant postdoctoral experience.
- Track record of scientific publications in high-profile journals
- Deep understanding of cell biology, immunology, cell-culture and cell-based assay development.
- Experience in drug metabolism and safety
- Demonstrated motivation, tenacity, innovation, creativity and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player with the ability to thrive in a fast-paced, multidisciplinary, matrixed environment
Preferred
- Expertise in immunology and/or molecular toxicology. Experience at the interface of drug metabolism and safety.
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
About this role
Arrowhead Pharmaceuticals is looking for a Senior Scientist I to join its Discovery Pharmacology team in Madison, working on RNAi-based therapeutics designed to silence disease-causing genes. You would design and execute in vitro, ex vivo, and in vivo studies to understand drug mechanisms of action, develop cell-based functional assays, and troubleshoot scientific challenges independently. The role involves close collaboration with biology and cross-functional teams, presenting findings internally to governance bodies and externally at conferences and in publications.
The position requires a PharmD or PhD in immunology, cell biology, molecular toxicology, pharmaceutical sciences, or pharmacology, plus at least two years of pharmaceutical industry or postdoctoral experience. You should have a publication record in high-profile journals, strong expertise in cell biology and cell-based assay development, and experience in drug metabolism and safety. The ideal candidate combines scientific rigor with problem-solving creativity, communicates clearly both orally and in writing, and works effectively in a fast-paced, multidisciplinary environment. Expertise in immunology or molecular toxicology is preferred, as is experience at the intersection of drug metabolism and safety.
This is an in-office, full-time role based in Madison, Wisconsin, with a salary range of $120,000–$130,000 and a competitive benefits package.
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Pay for this role
$120,000 to $130,000 per year
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