Director/Senior Director, Government Accounts - Nation

About Stoke: Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study.

Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts.

com/ Position Purpose: The Director/Senior Director, Government Accounts is a field-based market access role responsible for securing and optimizing coverage, reimbursement, and policy access for a medical benefit injectable product across state Medicaid fee-for-service (FFS) programs and Managed Medicaid health plans. This individual serves as the company’s primary access architect within the government payer channel, navigating the intersection of federal Medicaid statute, state-level policy, and medical policy development to ensure patients receive uninterrupted, appropriately reimbursed access to therapy. This individual will leverage deep government payer relationships to build Stoke’s presence from the ground up—translating the clinical and economic value of zorevunersen to state Medicaid decision-makers and securing favorable coverage post approval.

This is a launch-oriented, high-visibility position that requires expertise in rare pediatric/neurological disease in the government channel. The role requires sophisticated knowledge of state Medicaid, new drug review timelines, DUR board processes, and the policy levers that determine speed to coverage for a launch product. The candidate will have the ability to operate nimbly within Stoke’s growing commercial organization while partnering closely with our medical, commercial, government affairs, and patient advocacy colleagues.

Key Responsibilities

: Account Strategy & Launch Readiness Develop and execute pre-launch and launch-phase access strategies across Medicaid FFS and Managed Medicaid, establishing Stoke’s credibility with state agencies ahead of FDA approval. Serve as Stoke’s primary relationship owner and strategic point of contact across state Medicaid pharmacy and medical directors, DUR/P&T board members, and Managed Medicaid MCO leaders in priority states. Maintain a deep understanding of account-level policies, state drug review processes, competitive dynamics, decision timelines, and state priorities impacting access.

Develop multi-year state Medicaid access plans that anticipate policy shifts, IRA pricing dynamics, and competitive changes, balancing state-by-state tactical execution with a national access strategy. Government Payer Engagement & Coverage Proactively engage state Medicaid medical and pharmacy directors to secure informal billing guidance, coverage letters, or favorable fee-for-service payment determinations ahead of a permanent J code assignment. Monitor AMP-based reimbursement benchmarks, Medicaid Upper Payment Limits (UPLs), and state-specific drug fee schedules to provide payers with accurate, transparent pricing narratives that support appropriate reimbursement under the medical benefit.

Monitor federal and state Medicaid policy developments—including CMS guidance, CMCS informational bulletins, state plan amendments (SPAs), and 1115/1915 waiver activity—and translate implications for brand access strategy.