Senior Scientist, LNP, Process Development & Manufacturing

ElevateBio is a technology-driven company powering the industry forward by helping partners realize the potential of their therapies from design to commercialization. We have integrated a differentiated set of technologies, end-to-end services, and industry-leading manufacturing expertise to develop advanced therapies faster and more efficiently. The Role: We are seeking a highly skilled LNP Senior Scientist to join our process development team at ElevateBio.

The ideal candidate will have hands-on experience in LNP formulation, targeted LNP (tLNP) engineering through bioconjugation, and a complete understanding of LNP-based processes. As an LNP Scientist, you will be responsible for designing and executing LNP formulation studies while also working closely with cross-functional teams and external clients for the manufacturing of LNP-based therapeutics. Your work will be critical in advancing the translation of LNP therapeutics from development through large-scale manufacturing at ElevateBio.

What You’Ll Do

: Lead the execution for LNP formulation studies to support process characterization, technology transfer, and manufacturing readiness for LNP-based drug products. Work closely with cross-functional teams, including MSAT, AD, Quality, Manufacturing, and external clients, to support process development, scale-up and technology transfers. Characterize LNP and tLNP formulations using analytical techniques to evaluate size, PDI, zeta potential, encapsulation efficiency, lipid quantification, ligand density, conjugation efficiency, and formulation stability.

Analyze and interpret experimental data, identify process improvement opportunities, and communicate technical findings, project updates, and recommendations to internal stakeholders and external clients.

Requirements

: Education

D. in Pharmaceutical Sciences, Bioengineering, Biochemistry, Chemical Engineering, Biotechnology, Biomedical Engineering or a related discipline with 5+ years of industry experience in lipid nanoparticle (LNP) development or drug delivery, or a BS/MS degree in a related field with 12+ years of relevant industry experience . Minimum of 6 years working with LNP-based products in a process development or manufacturing setting.

Familiarity with GMP regulations, regulatory expectations, and preparation of technical documentation supporting CMC activities, technology transfer, and regulatory filings for LNP-based formulated products Proven record of manufacturing LNP-based products through either process development work or tech transfer activities Strong understanding and practical experience with LNP formulation, process development, including scale-up into GMP manufacturing with demonstrated expertise in LNP formulation development & optimization, tLNP development, and LNP purification. Ability to analyze and interpret data linking receptor engagement, ligand density, nanoparticle properties, cellular uptake, and delivery performance to guide tLNP optimization. , RiboGreen), lipid quantification, and stability assessments.

, Repligen) Ability to analyze complex experimental data, troubleshoot process challenges, and collaborate cross-functionally with MSAT, analytical development, manufacturing, and external partners.

Preferred Qualifications

Experience with targeted LNP development, including ligand conjugation strategies, functionalization approaches, and characterization of targeted delivery sy