Senior Manager, Human Resources (Commercial Business)

Position Title: Senior Manager, Human Resources Department: Human Resources Reports To (title): Executive Director, HR Business Partner Location: King of Prussia, PA | Hybrid Summary: At Paratek Pharmaceuticals , you'll join a team united by a shared purpose: improving the lives of patients with serious diseases. Guided by our core values – Purposeful, Passionate, Resourceful, and Collaborative – we empower our employees to make meaningful contributions, collaborate across functions, and help shape the future of our business. As a growing organization, we value curiosity, accountability, and teamwork.

We encourage our people to think creatively, embrace new challenges, and solve meaningful business problems together. We believe our people are our greatest strength and are committed to creating an environment where individuals can grow, lead, and make a lasting impact. Position Information: The Senior Manager, Human Resources serves as a trusted HR Business Partner to Commercial business leaders, translating enterprise and Commercial talent strategies into practical people solutions that support business performance, organizational effectiveness, and employee engagement.

Reporting to the Executive Director, Human Resources, this role partners closely with Commercial leaders and collaborates across HR Centers of Excellence to deliver integrated people solutions that advance business priorities. Acting as a trusted advisor, the Senior Manager provides consultation and coaching on talent management, organizational effectiveness, performance management, employee relations, and change management. Success in this role requires balancing strategic thinking with hands-on execution, building strong relationships, and helping leaders navigate people-related opportunities and challenges in a fast-paced, evolving environment.

The ideal candidate combines strong business acumen with broad HR expertise and the ability to influence leaders, manage competing priorities, and deliver practical, business-focused HR solutions.

Key Responsibilities

: Strategic Business Partnership Partner with Commercial leaders to understand business priorities and implement people strategies and HR initiatives that support organizational performance and business objectives. Provide consultative guidance to leaders on talent management, organizational effectiveness, workforce planning, leadership effectiveness, and employee-related matters. Build trusted relationships with leaders and employees, providing coaching and practical guidance on people-related issues while fostering a positive and high-performing work environment.

Identify organizational risks, talent gaps, and workforce opportunities, recommending practical solutions and partnering with HR leadership on more complex organizational challenges. Influence decision-making through trusted business partnership, thoughtful consultation, and data-informed recommendations. Talent & Organizational Effectiveness Partner with leaders to assess team effectiveness, organizational needs, and talent priorities, identifying opportunities to improve organizational performance and business outcomes.

Compensation

planning. Coach managers and leaders on effective people leadership practices, providing guidance on performance management, talent development, employee engagement, and organizational effectiveness. Partner closely with HR Centers of Excellence and Commercial leaders to deliver integrated talent solutions that support business priorities.

Support organizational change initiatives by helping leaders navigate change, communicate effectively, and build employee engagement.