Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed. The Opportunity The Senior Director, Trade & Distribution will lead execution of Praxis’ end-to-end trade and distribution strategy as the company advances toward commercialization. This role supports both rare disease and broader neurology launches, ensuring distribution, data, and partner ecosystems are operationally ready, compliant, and aligned to patient access and financial goals.

This is a hands-on leadership role for someone who can translate strategy into execution, manage complexity across multiple workstreams, and drive launch readiness in a fast-moving environment.

Responsibilities

Execute trade and distribution strategies across rare disease and broader market channel models Lead implementation and oversight of 3PL partners, including inventory flow, order-to-cash, reverse logistics, and SLA management Support selection, onboarding, and operational management of specialty pharmacy partners Drive implementation of data aggregation capabilities across 3PLs, specialty pharmacies, and digital pharmacy partners Ensure serialization readiness, DSCSA compliance, and audit preparedness across products Serve as the primary operational lead across external trade, distribution, and data partners Partner cross-functionally with Market Access, Finance, Patient Services, and IT to ensure aligned execution and launch readiness

Qualifications

and Key Success Factors

8–12+ years of experience in trade, distribution, market access, or specialty pharmacy Experience supporting commercial launches, ideally across rare disease and/or broader specialty markets Experience managing 3PLs, specialty pharmacy networks, and complex cross-functional implementations Strong understanding of channel strategy, commercialization infrastructure, and data flows Key Success Factors Strong executor who can turn strategy into action and drive decisions under real-world constraints High ownership and accountability with the ability to manage multiple complex initiatives simultaneously Clear, direct communicator who builds effective cross-functional and external partnerships Sound judgment and problem-solving skills in ambiguous, fast-paced environments Comfortable operating with low hierarchy, high autonomy, and candid feedback What Sets Successful Praxons Apart You challenge assumptions, surface risks early, and engage in healthy debate to improve outcomes You learn quickly, build context fast, and thrive in unfamiliar territory You balance urgency with rigor—moving quickly without compromising what matters most You care deeply about impact and keep patients at the center of decisions The physical and mental

Requirements

of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Compensation

Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class

package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans.

, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.

We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results.

Let’s achieve the impossible together!

Sr. Director of Trade and Distribution