Senior Infrastructure and Systems Engineer

Who We Are

: Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions.

Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. com or follow us on X (formerly Twitter) or LinkedIn . How we work: PIONEER : We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.

COLLABORATE : We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine. BELONG : We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

Kymera Therapeutics is seeking a Senior Infrastructure & Systems Engineer to serve as a technical peer and force multiplier for the Senior Director of Infrastructure & Operations. This role provides technical leadership for the organization's endpoint computing platform and broader infrastructure within a hybrid Microsoft ecosystem, serving as the senior engineering resource responsible for designing, implementing, securing, and optimizing endpoint management technologies while acting as the highest level of technical escalation for complex infrastructure issues. The successful candidate will drive the evolution of Kymera's modern workplace by leveraging Microsoft Intune, Microsoft 365, Entra ID, Windows client engineering, automation, and cloud technologies to deliver secure, scalable, and highly available endpoint services.

This position partners closely with Infrastructure, Cybersecurity, Identity, and Enterprise Applications teams to modernize endpoint architecture, improve operational maturity, and implement engineering best practices across the organization. The ideal candidate possesses a cloud-first engineering mindset while maintaining deep expertise across hybrid environments. They understand enterprise systems as interconnected platforms rather than isolated technologies and are comfortable designing solutions that improve security, automation, and user experience across the enterprise.

The right candidate operates independently, takes strong ownership of their work, and is committed to reducing single points of failure through automation and documentation.

Responsibilities

Endpoint Engineering and Modern Device Management Architect, implement, and maintain enterprise endpoint management solutions using Microsoft Intune and Company Portal Design and maintain application deployment strategies utilizing Win32 packaging, Microsoft Store integration, Microsoft 365 Apps, and PowerShell automation Develop and maintain configuration profiles, compliance policies, security baselines, remediation scripts, and update rings Engineer and optimize Windows Autopilot deployments including Enrollment Status Page (ESP) configurations, provisioning workflows, Windows Hello for Business, and lifecycle management Develop standards for endpoint configuration, provisioning, and device governance Lead initiatives to modernize endpoint management through cloud-native technologies Support macOS and iPadOS devices in an enterprise MDM context alongside Windows.