Scientist, Analytical Development and Quality Control

Company Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Nurix Therapeutics seeks an experienced Scientist to join the Analytical Development and Quality Control group. The Scientist will conduct analytical method development and material characterization studies to inform drug substance and drug product development. They will also provide operational oversight at external CDMO/CTL partners, manage reference standards and impurity markers, collaborate in CMC risk management, and author technical reports.

In Nurix’s laboratories, the Scientist will characterize material attributes and impurities by high resolution mass spectrometric and multidimensional chromatographic techniques. They will determine impurity structures, characterize material stability, and elucidate mechanisms of degradation. They will employ state of the art QbD approaches to develop and troubleshoot chromatographic test methods to accelerate and derisk QC activities performed externally at CDMOs and CTLs.

The Scientist will critically evaluate characterization data and communicate results in multidisciplinary teams. The ideal candidate must have demonstrated expertise in mass spectrometry and hands-on experience with liquid chromatography. Hands-on experience with two-dimensional liquid chromatography is a plus.

This position is onsite at Nurix headquarters in Brisbane, CA.

Key Responsibilities

Characterization and development studies at our internal laboratory: 2D-LC for impurity profiling of complex samples, derisking HPLC test procedures, and adaptation of incompatible methods to mass spectrometry Structural elucidation by high resolution Orbitrap Tribrid Mass Spectrometry QbD HPLC method development using multivariate DOE software Forced degradation and elucidation of degradation mechanisms Accelerated predictive stability studies and modeling of packaging configurations and long term stability Authorship of technical documents such as analytical development reports, stability reports, and storage statements Management of reference standards and impurity markers Manage and organize documentation and data Contribute to protocol development and oversight/troubleshooting of method transfers Liaise with Medicinal Chemistry, Bioanalytical, DMPK, and Preclinical departments Compliance with cGMP quality standards and internal SOPs Travel up to 5%

Required Qualifications

Advanced degree in a relevant discipline (Chemistry, Pharmaceutics, or related field).

Qualifications

Experience with accurate mass instrumentation such as Orbitrap Tribrid mass spectrometers Experience in operation of 2D-LC Experience in the determination of structures of small molecule impurities and/or metabolites Experience protein and/or ADC characterization by mass spectrometry Familiarity with gas chromatography, NMR, p