Earli tackles the #1 problem in the $100B cancer drug market: systemic toxicity. On-target/off-tumor effects force suboptimal dosing, reduced efficacy and sidelining some of the most potent drug classes such as cytokines. Earli’s BioAI approach flips this paradigm: Drugs are produced only where needed— in the tumor, by the tumor, against the tumor.

Cancer cells become their own drug factories, enabling localized immune activation, even in cold tumors. This was enabled by three core innovations: Extrahepatic lipid nanoparticles (LNPs) that reach tumors such as lung cancer AI-designed genetic switches that activate only in malignant cells by sensing transcription factor dysregulation Local production of immune therapies (TCEs, cytokines, multispecifics) at the tumor site — “produce locally, consume locally” Together, these technologies create a new biological control layer, allowing tumors to self-identify and trigger their own targeted immune attack—achieving specificity beyond current targeted or IO therapies. Earli plans to enter the clinic by mid-2027 with a Phase 1/2 lung cancer trial.

The company is backed by a16z, Khosla, Perceptive, Alex Gorsky, Marc Benioff, Breyer, Emerson Collective, Sands Capital and others. The SAB includes Jim Allison (Nobel Laureate, MD Anderson), Bob Langer (Co-founder Moderna, MIT), Phil Greenberg (Co-founder Juno), Amy Abernethy (frm. Principal Deputy FDA Commissioner), Bill Hait (former J&J EVP Oncology R&D), and Alan Ashworth (President UCSF Cancer Center).

The leadership team brings deep gene therapy, LNP, CMC and tech experience; CEO Cyriac Roeding previously led a $250M (11x return) exit.

Who You Are

You share our same sense of dedication, scientific passion and entrepreneurial spirit You work well in a fast-paced and extremely focused startup environment You are not only smart, but clever and constantly think outside the box You are able to make logical decisions in an instant when there is little time to evaluate You are a natural communicator and relationship builder You stay calm under high pressure and stress You have the ability to multi-task in a serious way, with an extreme attention to detail You become a representative of the core DNA of the company through

The Position Earli Inc. is currently seeking a top caliber Senior Scientist, Bio AI to join our Synthetic Bioengineering team.

Responsibilities

Leverage cutting-edge ML, bioinformatics, and high-throughput assay data to design cancer-specific synthetic promoters and novel genetic medicines that will directly impact Earli’s clinical pipeline. Train generative AI models for designing genetic medicines by leveraging Earli’s proprietary Massively Parallel Reporter Assay (MPRA) data as well as external data sets Contribute to wet lab experimental design and data evaluation to benchmark AI model performance against ground truth wet lab data and create a rapid iteration loop Perform routine computational analyses to analyze MPRA and other large experimental datasets using existing packages as well as bespoke analysis where needed. g.

g. g. GCP) with appropriate engineering adaptations as needed.