Principal Scientist, Immunology

About Jade Biosciences Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade’s lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development.

Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. com and follow the Company on LinkedIn . Role Overview The Research and Translational Medicine group at Jade is looking to add a Principal Scientist, Translational Research, to our team.

This role will provide scientific leadership across immunology-driven research activities that support Jade’s pipeline programs, including mechanism-of-action studies, disease biology assessment, indication evaluation, and translational strategy. The Principal Scientist will integrate literature, experimental data, and translational insights to strengthen program rationale, inform clinical development, and identify opportunities for pipeline expansion. This is an exciting opportunity to join a growing, highly collaborative biotech team and contribute to the advancement of potentially best-in-class therapies for autoimmune and inflammatory diseases.

S. West Coast, with occasional domestic and international travel. The position reports to the Executive Director, Research and Translational Medicine.

Key Responsibilities

Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications Present findings to internal governance teams and external scientific forums Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy

Qualifications

PhD in Immunology or related field with 8–12+ years of relevant industry experience is required Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms Strong understanding of drug development, including how preclinical and translational data inform clinical strategy Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus Experience working in cross-functional teams (e.g., Translational Medicine, Clinical, Nonclinical) Strong written and verbal comm