The Organization What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible. Through proprietary and versatile approaches, Entrada is advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne muscular dystrophy (DMD) who are exon 44, 45, 50 and 51 skipping amenable. Entrada has partnered with Vertex Pharmaceuticals to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1 (DM1). 2026 represents a catalyst-rich period for Entrada.

S. By year-end 2026, we anticipate four clinical-stage programs in our DMD franchise (ENTR-601-44, ENTR-601-45, ENTR-601-50, and ENTR-601-51). These programs are complemented by the ongoing clinical progress of our DM1 collaboration with Vertex (VX-670).

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families. The Perfect Addition to Our Team You are passionate about clinical trial research and driven to advance drug development through rigorous analytics. With a strong foundation in statistics and clinical methodologies, you combine classical techniques with cutting-edge innovations.

You thrive in fast-paced settings, handle competing priorities with ease, and eagerly step in where needed. You are results-oriented and collaborative, and you thrive when build strong relationships across teams to deliver impactful solutions. The Opportunity Reporting to the Head of Biometrics, this individual will contribute to daily statistical activities and support the development of statistical approaches for clinical trials.

Working closely with internal and external stakeholders, you will help manage a growing portfolio of trials. This role also offers the opportunity to support the continued growth of the biostatistics function at Entrada and gain valuable experience in a collaborative, fast-paced environment.

Responsibilities

Support statistical strategy for assigned drug programs, including input to clinical development plans, clinical study concepts and protocols design, SAPs, clinical study reports, regulatory documentation and associated publications. Accountable for oversight of the production of biostatistics deliverables (TFLs, including planned, post-hoc, and/or exploratory analyses) as performed by external resources. Provide statistical strategy support and input in protocols, CSRs, and scientific presentations and manuscripts.

Review the randomization procedures and oversight of the production of randomization lists.

Requirements

defined in the study protocol are met. Oversee outsourced statistical CRO activities and deliverables, ensuring high quality and timely delivery. Produce innovative tools and methodologies for statistical analysis through literature review.

Participate in the development of department strategies and cross functional initiatives on standards, infrastructure, and processes. The Necessities At Entrada, our passion for science, our devotion to patients and our values drives our behavior: Humanity - We genuinely care about patients and about one another. Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.

Creativity - We are creative problem solvers.

Principal Biostatistician