Associcate Scientist II (Contract), Drug Product Analytics

Join our Mission to Protect Humankind! Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning.

Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values: *RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind. *LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives. *MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary: Vaxcyte is looking for an energetic and talented individual to join our Drug Product Development team. The candidate must have knowledge of and practical experience in analyzing and characterizing biomolecules (proteins, polysaccharide conjugates, vaccines) using a variety of methods, especially immunoassays and multiplexed immunoassay formats. Experience in analyzing vaccine and adjuvant-containing formulations is a plus.

In addition, Vaxcyte is looking for an experienced and flexible individual who would be comfortable working on multiple projects at once, with fluid prioritization to enable aggressive timelines. This position is for a lab-based scientific role and requires excellent scientific judgement, independence, rigor, and thorough record-keeping. Essential Functions: Execute routine studies to support internal release, development, and stability samples using a variety of analytical techniques, particularly multiplexed immunoassays (such as MSD) across Drug Product working groups, ensuring high-quality data generation and reporting.

Execute non-GxP stability study analysis for thermal, freeze/thaw, and agitation as well as container closure system evaluation for both Drug Substance and adjuvanted vaccine Drug Product materials. Execute and contribute to the development of workflows on automation systems, such as Hamilton, Tecon, Integra. Design and execute periodic testing of critical assay reagents, such as antibodies, QC samples, calibrators amongst others.

Analyze and interpret complex assay data, identify trends or deviations, and communicate findings to project teams to support development decisions Support the Vaxcyte PCV and VAXA1 products, external analytical, and manufacturing CMOs to enable tech transfer and implementation of processes and analytical methods. Vaxcyte is looking for a flexible individual who would be comfortable working on multiple projects at once, with fluid prioritization to enable aggressive timelines. This position is for a scientific role, which is predominantly lab-based, requiring excellent scientific judgement, independence, rigor, and thorough record-keeping.

Requirements

: BSc or MSc in Biochemistry, Molecular Biology, Immunology or related field preferred, with minimum 2-4 years of experience in the pharmaceutical and/or biotechnology industries. Hands-on experience developing, optimizing, and executing single-plex and multiplex immunoassays (MSD, Luminex, Multi-arrays) with demonstrated ability to troubleshoot assay performance and interpret assay data. Hands-on experience with executing workflows on automated liquid handling platforms.