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Flagship Pioneering, Inc. — New York, England
About us Appnovation is a global, full-service digital partner that combines Strategy, Experience & Design, Engineering and Managed Services. We build digital solutions that deliver real impact today and serve as foundations for future growth. Bold ambition.
Practical action. Endless possibilities.
About The Role
Join forces with Appnovation to deliver high-impact results for one of our key strategic partners - a global leader in their field. This engagement offers a unique vantage point into a world-class organization with exceptional opportunities for professional growth and long-term career advancement. At our partner organization, the mission is to create breakthroughs that change patients’ lives, and the company has recently rebuilt its entire technology operating model to deliver on it.
The organization is becoming AI-native and agentic-supported, placing enterprise AI platforms in the hands of all 80,000 colleagues. For a designer, this is a rare, career-defining moment: a historic 177-year-old company rewiring itself around AI, feedback loops measured in days, and design decisions that shape how an entire company works and how medicines reach patients. We are seeking an innovative Manager, AI-First Design to help build these transformative platforms.
In this hands-on and execution-focused individual contributor role, you will design from inside the team—working daily with engineers, experience architects, and product owners. You will move AI-native digital products from concept to real applications, leveraging AI tools and an internal design system to dramatically shorten traditional design cycles. You will make day-to-day design decisions, surface larger strategic tradeoffs to leadership, and grow your fluency in how LLM-enabled systems behave, communicate, and act.
Key Responsibilities
Hands-On Design Delivery: Work as an engaged, hands-on contributor within a cross-functional pod (engineers, experience architects, and product owners). Deliver rapid prototypes and digital products for assigned priority projects using AI-driven design tools. Rapid Iteration: Partner directly with Product and Engineering to iterate on MVPs and proof-of-concepts, validating business ideas within days.
Agentic & Conversational Design: Design core components of Agentic AI experiences where systems plan, make decisions, call tools, and complete multi-step workflows with humans in the loop. Contribute end-to-end to Conversational UX (dialog flows, conversation state, turn-taking, confirmations, error recovery, escalation, and safe fallback behaviors). Assistant Behavior Patterns: Apply and help refine assistant behavior patterns (tone, grounded responses, refusal patterns, transparency cues, and trust-building interactions).
Interactive Prototyping: Build dynamic, interactive prototypes optimized for cross-platform use, simulating agent behavior rather than static screens to validate workflows and surface risks quickly. Design System Contribution: Apply and extend the internal design system, contributing feedback on AI-first patterns and maintaining consistency across prototypes. Documentation & Handoff: Build clear design documentation for assigned work (templates, components, specifications) and leverage AI tools to streamline developer handoff.
1 AA) across all designs, applying inclusive design practices for diverse user needs. Product-Minded Contribution: Help frame problems, contribute to hypotheses, and connect design decisions directly to measurable outcomes (adoption, task success, time-to-resolution, trust, and quality indicators).
What We Are Looking For
Must-Have (Basic
Qualifications
) Experience: 4-6 years of progressive UX design experience with a track record of contributing to high-impact digital products.