Senior Manager, Portfolio Management & Operations

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.

As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Revolution Medicines is seeking a motivated individual with experience in CMC, project and portfolio management, and/or life sciences management consulting to play a critical role within the Portfolio Management group of the Pharmaceutical Development and Manufacturing (PDM) organization. This position will serve as a key business partner supporting portfolio analytics, governance operations, resource and cost management, and strategic cross-functional initiatives.

The role will partner closely with cross-functional stakeholders to drive execution of critical business processes, support decision-making, and improve organizational effectiveness across a growing portfolio of discovery, development, and commercial programs.

Responsibilities

: Partner with PDM leadership and cross-functional stakeholders to support portfolio planning, business operations, and strategic decision-making across the organization. Develop analyses, insights, and recommendations that enable effective prioritization, resource allocation, risk management, and execution of business objectives. Drive cross-functional planning and governance activities by facilitating stakeholder alignment, supporting decision-making forums, and ensuring effective follow-through on key actions and commitments.

Develop and maintain portfolio reporting, metrics, dashboards, and other decision-support tools to provide visibility into portfolio performance, organizational capacity, risks, and opportunities. Support budgeting and long-range planning activities through data analysis, scenario modeling, and business insight generation. Lead or contribute to strategic initiatives and operational excellence efforts aimed at improving business processes, organizational effectiveness, and scalability.

Apply structured problem-solving and analytical approaches to address complex cross-functional challenges and support informed decision-making. Build strong partnerships across PDM and adjacent functions to promote transparency, alignment, and effective execution of key priorities. Prepare and deliver clear, concise, and compelling communications, presentations, and recommendations for audiences ranging from working teams to senior leadership.

Sc. in a scientific, engineering, business, or related discipline, with 5+ years of experience within a CMC, Project and Portfolio Management, and/or life sciences management consulting organization. Robust analytical and problem-solving skills with experience in scenario planning, forecasting, resource modeling, and business analytics; demonstrated ability to translate analytical insights into executive-level communications.

Strong scientific and business acumen with the ability to connect data, portfolio priorities, resource constraints, and organizational objectives into actionable recommendations. Demonstrated intellectual curiosity and learning agility, with a willingness to quickly develop expertise in new business processes, functional areas, and technical domains. Ability to influence without authority and build productive working relationships across functions and organizational levels.