Executive Director, Scientific & Medical Excellence

Mavericks Wanted When was the last time you achieved the impossible? read on In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way.

We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry.

" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical thoughtful use of AI to improve clarity, speed, and quality of work.

What You'Ll Do

The Executive Director, Scientific Medical Excellence is a senior leadership role within Medical Affairs, accountable for the cross-cutting scientific capabilities and programs that serve BridgeBio’s portfolio. This leader will own evidence generation planning, the investigator-sponsored trial (IST) and sponsored research portfolio, Medical Information, expanded access / compassionate use programs, and the integration of artificial intelligence into Medical Affairs ways of working—while driving global planning and alignment across affiliates and functions. This individual will build and scale the operating model, governance, and standards that allow Medical Affairs to act with scientific rigor, speed, and compliance.

The role requires deep expertise in rare disease, the maturity to lead in a matrixed, fast-paced environment, and the vision to modernize how a medical organization generates and exchanges scientific evidence. The role partners closely with Clinical Development, Regulatory, Commercial, Market Access, HEOR, Patient Advocacy, and Field Medical.

Responsibilities

Evidence Generation Planning Lead the development of the integrated evidence generation plan, in partnership with HEOR, aligned to overarching medical and asset strategy and informed by clearly prioritized scientific and stakeholder evidence gaps. Coordinate the planning of real-world evidence (RWE), registries, natural history studies, database analyses, and Phase 4 / post-marketing studies in partnership with Clinical Development, HEOR, and Biostatistics.

Requirements

, and that data are disseminated through a coordinated publication strategy. Investigator-Sponsored Trials (IST) Sponsored Research Partnerships Own the strategy, governance, and end-to-end operations of the investigator-sponsored trial (IST) program, including the review committee, scientific prioritization, and funding decisions aligned to medical strategy and evidence gaps. Develop and manage sponsored research collaborations and external research partnerships with academic centers, consortia, and cooperative groups.

Establish transparent processes for proposal intake, contracting, milestone tracking, publication expectations, and compliant oversight of supported research. Partner with Legal, Compliance, Finance, and Regulatory to ensure all externally sponsored research meets internal standards and applicable regulations. Medical Information In partnership with the Bridge Bio MI Lead, manage affiliate Medical Information function, including strategy, content, and operations for responding to unsolicited requests from healthcare professionals, patients, and other stakeholders.

Oversee development and scientific governance of standard response documents, FAQs, and the medical information content library, ensuring accuracy, balance, and compliance.