Postdoctoral Fellow/ Scientist I , Synthetic Spatial Omics

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.

org/immune-cell-reprogramming/ ) is an independent nonprofit research institute that brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision We pursue large scientific challenges that cannot be pursued in conventional environments We enable individual investigators to pursue their riskiest and most innovative ideas The technologies developed at Biohub facilitate research by scientists and clinicians at our home institutions and beyond Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution. org/synthetic-spatial-omics/ ) advances our understanding of engineered immune cell function within their native microenvironment to design better cell therapeutic approaches.

Toward this goal, we develop and integrate state-of-the-art immune cell engineering, imaging-based and sequencing-based multi-omics, and machine learning/AI frameworks. We bring together scientists with diverse expertise to pursue highly interdisciplinary scientific challenges. The Opportunity We are seeking an exceptional Postdoctoral Fellow/ Scientist I focusing on cell engineering with a creative mindset to drive innovative engineering and investigation of programmable immune cells with single-cell spatial precision.

The successful candidate will integrate synthetic biology, spatial multi-omics, and systems-level analysis to engineer programmable cellular functions, investigate their activities in situ, and identify the molecular drivers of specific functional states. This position offers the opportunity to translate unconventional ideas toward advancing cell therapies, while developing expertise at the intersection of technology development and fundamental discovery within a highly collaborative, interdisciplinary research environment.

What You'Ll Do

, receptors and transcription factors). , seqFISH+) to uncover cellular functions and engineering principles. Analyze high-dimensional imaging and sequencing datasets using computational approaches to identify organizational and regulatory principles.

Collaborate closely with researchers across genomics, immunology, machine learning, and related disciplines. Contribute to preprints, publications, presentations, and open science practices. What You'll Bring PhD in Synthetic Biology, Systems Biology, Bioengineering, Immunology or a closely related discipline.