Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking a Senior Scientist as part of the R D Leadership Development Program based in Philadelphia, PA.

Role Overview The Early Career Leadership Program at Legend Biotech is a strategic, enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers. Rooted in our commitment to cultivating enterprise-minded, value-driven leaders, this program provides structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions. The R D Hi-Po Leadership Development Program is a project-based, enterprise leadership accelerator designed for high-potential PhD graduates who aspire to shape the future of cell and gene therapy.

5–3 years, participants will lead 3-4 high-impact, 8-12-month strategic projects across R D, Preclinical Development, Technical Development, Business Development and Regulatory Affairs. This immersive experience is built to cultivate scientific leaders capable of translating discoveries into development, advancing complex pipeline programs, and influencing cross-functional strategy. Participants will gain enterprise exposure, executive mentorship, and access to a formal Annual Leadership Development Series focused on strategic thinking, regulatory and clinical acumen, and senior leadership readiness.

Join us in advancing the frontiers of cell and gene therapy—where your discoveries can redefine treatment paradigms and transform patient outcomes worldwide We are seeking a highly motivated Senior Scientist to join our growing In Vivo CAR-T Cell Therapy team. The successful candidate will contribute to the development of our in vivo CAR-T platform and pipeline by leveraging expertise in cellular immunotherapy, virology, and immunology. This role requires scientific excellence, strong collaboration skills, and the ability to drive projects in a fast-paced environment.

Join us in redefining what’s possible and build a career where your growth and patient impact go hand in hand.

Key Responsibilities

Design and execute research projects to drive innovation of cell and gene therapy platforms and advance pipeline development. Develop and optimize assays, including but not limited to lentiviral vector production and titration, advanced multi-parameter flow cytometry, Incucyte, ELISA, cytotoxicity assays, and PCR-based analyses. Conduct in vitro and in vivo studies to evaluate potency, function, and safety of drug candidates.

Collaborate closely with cross-functional teams to evaluate novel designs and generate robust, reproducible, and data-driven conclusions. Analyze, interpret, and document experimental results in a timely and highly organized manner, maintaining accurate scientific records and ensuring data integrity. Contribute to scientific strategy, experimental planning, and technology innovation to support pipeline advancement.

Requirements

PhD in Immunology or a related discipline.