R&D Manager Leadership Development Program, Solid Tumor

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking a R D Manager Leadership Development Program, Solid Tumor as part of the R D Leadership Development Program based in Philadelphia, PA.

Role Overview The Early Career Leadership Program at Legend Biotech is a strategic, enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers. Rooted in our commitment to cultivating enterprise-minded, value-driven leaders, this program provides structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions. The R D Hi-Po Leadership Development Program is a project-based, enterprise leadership accelerator designed for high-potential PhD graduates who aspire to shape the future of cell and gene therapy.

5–3 years, participants will lead 3-4 high-impact, 8-12-month strategic projects across R D, Preclinical Development, Technical Development, Business Development and Regulatory Affairs. This immersive experience is built to cultivate scientific leaders capable of translating discoveries into development, advancing complex pipeline programs, and influencing cross-functional strategy. Participants will gain enterprise exposure, executive mentorship, and access to a formal Annual Leadership Development Series focused on strategic thinking, regulatory and clinical acumen, and senior leadership readiness.

Join us in advancing the frontiers of cell and gene therapy—where your discoveries can redefine treatment paradigms and transform patient outcomes worldwide We are seeking a highly motivated Senior Scientist to join our growing In Vivo CAR-T Cell Therapy team. The successful candidate will contribute to the development of our in vivo CAR-T platform and pipeline by leveraging expertise in cellular immunotherapy, virology, and immunology. This role requires scientific excellence, strong collaboration skills, and the ability to drive projects in a fast-paced environment.

Join us in redefining what’s possible and build a career where your growth and patient impact go hand in hand.

Key Responsibilities

Participate in solid tumor team’s routine drug development candidate selection to support pipeline development. Participate in the development of new in-house enabling technology for solid tumor, including new armor design and testing, in vitro model development, assay development, single cell characterization. Propose new initiatives for solid tumor in vivo CAR-T and work with cross-functional team for execution.

Requirements

Recent PhD graduate (within the last 5 years) in Biological Sciences, Molecular Biology, Microbiology, Immunology, Biochemistry, Chemistry, Cell Biology, or related life sciences discipline. 2-3 years of research experience (academic or industry); life sciences or translational research experience preferred. Experience in Cell Therapy for solid tumor is preferred Demonstrated record of scientific rigor, innovation, drive and analytical skills.