Company Overview: Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self-replicating RNA, SignalPath targeted delivery, and logic-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety. Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease.

Its initial program, STX-001, an intratumorally delivered LNP-encapsulated self-replicating RNA expressing IL-12, has demonstrated preliminary evidence of systemic immune activation and anti-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX-003 is designed for tumor-targeted expression and avoidance of off-target expression. STX-003, which is expected to enter the clinic in mid-2026, has the potential to be a major step forward for the fields of genetic medicine and oncology.

Strand is also advancing STX-005, an in vivo CAR-T program designed to enable controlled, durable expression and repeat dosing. Founded by MIT synthetic biology pioneers, Strand has raised over $250 million and is headquartered in Boston, MA. Become the next standout single strand!

Job Summary: Strand is looking for people who have the enthusiasm and motivation to be a highly contributing member of a small but extremely productive team. This opportunity will offer the employee the ability to work in a matrix-based environment and be a part of the future strategy of the company. We are looking for a highly motivated and innovative candidate for the role of Associate Scientist I/II, Technical Operations Automation.

The expectation is that the Associate Scientist I/II will have experience with developing experiments and assays related to the LNP/mRNA manufacturing process, as well as experience working with automated lab instruments - especially liquid handler programming and method development. Reporting to Principal Associate Scientist of Technical Operations Automation, the right candidate will be an agile problem solver and strategic thinker that brings a leadership presence and enthusiasm for Strand, along with a desire to develop new skills surrounding lab automation overall. The candidate will have, and continue to develop, broad interests in overall Technical Operations processes, maintaining close communications with related teams and seeking out opportunities to apply automated methods towards increasing throughput and reliability.

Responsibilities

: Close collaboration with scientific staff on various teams (primarily analytical operations/development teams, as well as process development) to develop, automate and implement automated methods. Continued monitoring of the usage of automated methods, including training individual operators on performing these methods, troubleshooting and addressing any weak points Maintaining and repair automated systems. Executing studies for process improvements and advancements.

Support screening, optimization, and scale-up efforts across Tech Ops teams. Independently identify key areas within analytical and process development operations for optimization, implementing high-throughput automation tools to increase efficiency and consistency. Continuous optimization of existing automated methods, programming of operational tools that can be applied across methods.

Continuous learning across lab instruments – seeking out new opportunities for expanding both lab skills as well as programming and development. Maintenance of a broad understanding of the lab automation industry as a whole, identifying novel methods and instruments to improve processes.

Qualifications