Principal Product Manager, Clinical Trials Intelligence

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development.

As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. This role will define and deliver product strategy across the clinical trial continuum, from study design and startup through trial conduct, submission readiness, and post-approval safety monitoring. You will shape Clinical Trials Intelligence capabilities on RevCore, our enterprise data and AI platform, with a clear mandate to improve trial execution, enrollment predictability, data readiness, submission readiness, inspection readiness, and safety monitoring.

You will work on high-stakes products where trust, usability, traceability, and speed directly affect trial execution, regulatory readiness, and patient impact. This role focuses on product strategy, user outcomes, workflow design, adoption, and measurable impact, in partnership with clinical, regulatory, safety, medical, data, technology, quality, vendor, and system owner teams. Own Clinical Trials Intelligence strategy and outcomes Define the vision and roadmap across study design, startup, trial conduct, monitoring, data review, submission readiness, and post-approval safety monitoring.

Build a Now, Next, Later roadmap from foundational clinical data products to operational intelligence, automation, and AI-enabled decision support. Set success metrics tied to study startup cycle time, enrollment predictability, data quality, database lock readiness, submission readiness, inspection readiness, safety monitoring, and adoption. Prioritize capabilities that reduce manual work, improve clinical decision-making, detect risk earlier, and scale across studies and programs.

Build products around clinical trial workflows and decisions Understand workflows across Clinical Development, Clinical Operations, Data Management, Biometrics, Regulatory, Safety, Medical, Clinical Supply, and study teams. Design products around key decision moments such as protocol design, site selection, enrollment planning, risk monitoring, data review, database lock readiness, submission readiness, and safety signal review.

Requirements

, user stories, evaluation criteria, and prioritized capabilities. Build products that turn clinical, operational, safety, regulatory, and vendor data into decision-grade insights, not just dashboards or system reports. Establish trusted, reusable clinical trial capabilities Partner with technical teams, vendors, and system owners to deliver priority Clinical Trials Intelligence capabilities across RevCore and core clinical platforms.

Clarify trusted sources and systems of record for key clinical trial data, including protocols, studies, sites, subjects, visits, endpoints, deviations, adverse events, labs, biomarkers, milestones, and submission artifacts. Ensure products support data quality, metadata, lineage, usability, governance, access controls, auditability, traceability, validation, and compliance expectations.