Senior Director, Program Management

About Summit: Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality.

Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence. Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology.

Summit has multiple global Phase 3 clinical studies, including: Non-small Cell Lung Cancer (NSCLC) HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI. HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC. HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.

Colorectal Cancer (CRC) HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy. Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.

Overview The Senior Director of Program Management provides strategic and operational leadership across multiple development programs and/or a portfolio of assets, driving alignment between Research, Development, Business Strategy, Manufacturing, and execution. This role has enterprise-level impact on initiating new indications, pipeline prioritization, and long-range value creation from early development through regulatory approval. The Senior Director serves as the primary point of contact for key programs to executive leadership, ensures disciplined program governance, and strengthens the Program Management function as the organization scales.

This position reports to the VP, Program Management and may have people leadership responsibility.

Responsibilities

Strategic Program Portfolio Leadership Manage multiple programs or a therapeutic portfolio to maximize pipeline Partner with executive leadership on program, indication, and portfolio strategy, including prioritization and sequencing Define and oversee major milestones, decision points, objectives, and inflection points across programs Lead scenario planning, trade-off analyses, and decision frameworks to support executive decision-making Ensure alignment across Development, Regulatory, Manufacturing, and Corporate Strategy Cross-Functional Executive Leadership Lead and integrate complex cross-functional workstreams across Research, Development, Regulatory, and Manufacturing Facilitate effective decision-making and accountability across global teams and external partners Present clear insights, recommendations, and program status to C-suite and senior leadership Mentor and develop Program Management leaders and strengthen organizational capability Program Execution Governance Oversee end-to-end program execution, including activation of new indications post–Go decision Ensure consistent application of program management standards, dashboards, and governance models Chair timely, efficient, and action-oriented team meetings to coordinate operations