Scientist / Senior Scientist, Assay Development (Reagents)

About Glyphic: At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised $80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What We Are Looking For

in you Glyphic is seeking a Scientist or Senior Scientist to build and sustain the reagent supply infrastructure that powers our single-molecule proteome sequencing platform. In this role you will own the full reagent lifecycle — from early formulation and characterization through stability qualification, QC method development, and lot release — ensuring that every critical material entering a multi-cycle expansion run meets Glyphic's performance standards. The ideal candidate brings deep hands-on expertise in biochemical reagent development with a quality-by-design mindset: methodical in experimental approach, rigorous in documentation, and proactive in building the frameworks that sustain consistency at scale.

You have experience not just characterizing reagents but qualifying them — setting acceptance criteria, gating go/no-go decisions on incoming lots, and maintaining the provenance records that high-stakes single-molecule runs demand. You are comfortable working at the bench and translating your findings into SOPs, QC protocols, and reagent inventories that the broader Assay Development team can rely on. This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

What You’Ll Do

Reagent Development Formulation Lead assay reagent development activities, including formulation, characterization, and optimization, for components used in ProSE single-molecule expansion and library preparation workflows, including enzymes, oligos, beads, and solvents. The materials in scope extend beyond standard biological reagents to include chemically reactive compounds and environmentally sensitive materials susceptible to degradation by oxygen, humidity, light, and temperature fluctuations. Working with these materials demands a chemistry-aware approach to formulation, handling, and storage.

Characterize reagent performance using design-of-experiments (DOE) approaches, systematically varying formulation conditions, buffer composition, excipients, and process parameters to establish operating bounds and define product specifications. Design and execute experiments to evaluate reagent performance in end-use assay configurations; develop a mechanistic understanding of how reagent composition, lot variability, and environmental sensitivity impact expansion assay outcomes. Design and execute reagent storage stability studies under accelerated and real-time conditions; develop stability-indicating assays; interpret results against established product specifications and flag out-of-spec trends proactively.

QC Framework Lot Qualification Build and implement a QC and control framework for platform reagents, including acceptance criteria, lot release protocols, and QC assay development, to support reliable, consistent supply to the Assay team. Develop, qualify, and transfer QC test methods for reagent characterization and lot release, including HPLC, fluorescence-based functional assays, and physical characterization methods; set product, process, and incoming material acceptance criteria in collaboration with Assay and cross-functional partners. Qualify each reagent lot prior to use in multi-cycle or KOL runs; execute hands-on QC testing encompassing physical, chemical, and functional characterization; gate go/no-go decisions on input materials and maintain provenance records for high-stakes runs.

Maintain batch records and quality documentation in accordance with internal standards.