About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. , Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else.

We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit.

Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day.

Position Title: Portfolio Strategy Senior Analyst Department: Portfolio Strategy Reports To: Director, Portfolio Strategy Location: Evanston, IL – On-site 4 days per week (Mon to Thurs) Job Overview The Portfolio Strategy Senior Analyst will support both Kardigan’s portfolio strategy and business development activities, contributing to the evaluation, prioritization, and optimization of internal R D investments as well as the evaluation of external opportunities. This role will contribute to strategic decision-making through financial and deal modeling, portfolio analytics, and cross-functional business insights that inform investment decisions and enterprise priorities. The Senior Analyst will work closely with leaders across Portfolio Strategy, Finance, R D, Corporate Strategy, and Business Development to assess portfolio opportunities, model scenarios, and develop data-driven recommendations.

The ideal candidate combines strong analytical and financial capabilities with intellectual curiosity and a passion for learning in a fast-paced biotechnology environment. This role requires attention to detail and the ability to communicate complex analyses clearly to stakeholders and senior leadership. , Claude) and emerging AI-enabled approaches to portfolio analytics and decision-making, along with comfort operating in a fast-changing, AI-driven culture, is highly valued.

Responsibilities

Support enterprise portfolio strategy and prioritization efforts across discovery, clinical-stage, and lifecycle programs Build and maintain financial and deal models to evaluate portfolio investments and external opportunities, including risk-adjusted NPV analyses, deal valuation, and scenario modeling Support business development evaluations, including deal modeling, valuation of external opportunities (in-licensing, partnerships, M A), and due diligence support Contribute to corporate strategy and long-range planning initiatives as needed Develop portfolio analytics, dashboards, and presentations to support executive decision-making and governance discussions Partner cross-functionally with Finance, R D, Clinical, Commercial, and Corporate Strategy teams to evaluate trade-offs, risks, and resource allocation