Supervisor, Lab Operations (AM Shift, Tues - Sat)

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time.

Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. Shift Details: Tuesday - Saturday (6am - 2:30pm) Training hours may be different from your shift schedule.

Summary: A CLS Supervisor performs and reports on clinical laboratory testing that aids physicians in diagnosing and treating patients. A key part of the role is supervising team members and ensuring that all laboratory procedures are followed for specimen handling, next-generation sequencing (NGS) processes, test analyses, and the accurate maintenance of patient records. In our lab, we foster a positive, friendly, and team-based environment.

We all pitch in to achieve our common goals and support each other. You'll work in a dynamic atmosphere, gaining hands-on experience at multiple benches, including extractions, library preparation, and sequencing. You'll also partner with our lab assistants to coordinate pre-analytical and post-analytical tasks.

Responsibilities

: Perform and report clinical laboratory testing on patient samples to aid physicians diagnose and treat patients. This includes the following areas: Extractions Library Preparation Enrichments Sequencing Handle and process all patient specimens according to laboratory procedures, ensuring accurate and timely record-keeping and reporting of results. Select, implement, and evaluate quality control materials for statistical process control of laboratory assays.

Troubleshoot assays and equipment when quality control materials fail to perform as expected. Document all corrective actions taken when test systems deviate from established performance specifications. Assist in audits by regulatory bodies like CAP and external customers.

Participate in activities that support the laboratory's necessary licensure, including quality management and on-site inspections. Identify and correct problems that may negatively affect test performance or result reporting. If a problem cannot be immediately corrected, notify a supervisor, clinical consultant, or director.

Train other CLS and lab personnel on laboratory methods. Monitor the activities of non-licensed staff. Provide guidance to team members on troubleshooting and deviation investigations.

Assist in assay development activities. Demonstrate strong analytical skills and independent critical thinking. Apply technical and functional knowledge to help the team meet its goals.

Work independently to identify and resolve complex, open-ended problems.

Requirements

: Education: Bachelor's degree, preferably in sciences or related discipline. Licensure: Valid California Clinical Laboratory Scientist (CLS) or Clinical Genetic Molecular Biologist Scientist (CGMBS) license. Experience: At least four years of CLS experience in a clinical laboratory environment.

Minimum 1 year experience in a Lead role is required. Preferred Skills: Experience with manual DNA/RNA extractions, manual library preparation, and automated liquid handlers. 70 per hour plus applicable shift differential.

The offer will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors.