Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence.

It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency. Days Onsite: Monday Tuesday Summary: The Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products.

Further, the Senior Bioinformatics Scientist will work closely with our clinical evidence generation teams, applying our cell-free technology solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection.

Responsibilities

: Design and develop novel cell-free technologies and products Collaborate closely with laboratory scientists to design experiments to develop and evaluate novel applications for cell-free DNA assays Draw on deep experience with genomics and statistics to model and improve performance of cell-free assays and features Synthesize large datasets to develop and evaluate new biological and technological hypotheses Partner with the clinical evidence generation team to ensure the applicability and evaluate the performance of novel assays or feature improvements Maintain a strong working knowledge of literature covering technological developments in the cell-free DNA and liquid biopsy space Publish results and present at conferences in exciting areas, including cell-free DNA and cancer genomics

Requirements

, Python, R) A track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects Experience publishing and presenting scientific results The hiring range for this position is $155,000 to $190,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors.

Compensation

package, in addition to a full range of medical, financial, and/or other

Benefits

, dependent on the level and position offered. Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations.

and privileges of employment, please let your recruiter know, if/when they contacts you.

Sr. Bioinformatics Scientist – Novel Cell Free DNA Applications