Software Engineer 2

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample.

In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited.

Personalis is based in Fremont, California. Summary: We are seeking a Software Engineer II to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms.

You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment.

Responsibilities

: Design, develop, test, and maintain software systems and features supporting laboratory operations. Develop and optimize backend services and APIs using Python and/or Java. Implement solutions using a variety of database technologies, including relational and graph databases.

Take ownership of deploying and maintaining services in our AWS cloud environment. Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability. Troubleshoot and resolve complex technical issues in development and production environments.

Requirements

into robust technical solutions.

Qualifications

S. degree in Computer Science, Engineering, or a related technical field. 2-5 years of professional software development experience.

Strong proficiency in at least one programming language such as Python or Java. Proven experience building and deploying applications on AWS. , PostgreSQL, MySQL) and developing REST APIs.

, Github, Bitbucket) and CI/CD concepts. Excellent problem-solving skills and the ability to work independently on complex tasks. Preferred: Experience with web frameworks like Flask or FastAPI.

js). Experience in the life sciences, healthcare, or another regulated industry. , Docker).

Exposure to graph databases or NoSQL technologies. What You’ll Gain: Opportunity to take ownership of significant features and projects from design to deployment. Deepen your expertise in AWS services and cloud architecture.

Gain valuable experience working in a regulated life sciences environment. Clear pathways for career growth into a senior engineering role through mentorship and impactful work. The hiring range for this position is $130,000 to $155,000 per year, which may factor in various geographic regions.

The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors.

Compensation

package, in addition to a full range of medical, financial, and/or other b