About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. , Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else.

We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit.

Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day.

Job Title: Sr. Manager - Project Manager, Digital Health Technology (DHT) eCOA Position Overview Onsite 4 days a week - M-Th The Project Manager of Digital Health Technology (DHT) eCOA will serve as a critical bridge between clinical operations, data management, clinical quality, and external technology partners, holding ultimate accountability for the successful implementation, quality, and compliance of patient-facing digital tools. This role combines a clinical operations background with deep specialized expertise in eCOA system, and wearable device development processes.

The ideal candidate will manage the technical trial lifecycle from study design to close-out. This role requires an agile, innovative mindset to challenge status-quo thinking and requires travel—up to 25%—to support investigator meetings, vendor audits, and internal initiatives.

Key Responsibilities

Serve as the primary operational Subject Matter Expert (SME) and escalation point for assigned digital health technologies, including eCOA (ePRO, ClinRO, ObsRO), eConsent, wearables, and sensors. Provide technical and operational input directly into protocol development as it relates to digital tools and technologies. Own end-to-end technical project timelines, authoring, reviewing, and formally approving study specifications, user requirement documentation, and the execution of User Acceptance Testing (UAT), including managing the acquisition of COA instrument licenses Leverage a deep clinical operations foundation to plan, execute, and monitor proactive mitigation plans for complex operational challenges Liaise with cross-functional team representatives and study teams to ensure cohesive trial execution, align technical data flows with the study's Medical Monitoring Plan, and oversee the execution of the study monitoring plan as it pertains to digital tools, data compliance, and technical trial site performance.

Directly manage specialized vendor performance at the trial level, conducting root cause analyses for system variances, identifying and implementation of corrective actions (CAPAs), and providing technical problem resolution support.

Sr. Manager - Project Manager, Digital Health Technology (DHT) & eCOA