Who We Are

: Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description : We are seeking a scientist to join our Peptide Chemistry team. In this role, you will drive peptide drug discovery projects that sit at the nexus of empirical medicinal chemistry and Calico’s proprietary Machine Learning (ML) peptide design platform. You will collaborate cross-functionally with ML scientists, medicinal chemists, automation specialists, and biologists to explore structure-activity relationships (SAR).

By leveraging a rapid design-make-test cycle, you will accelerate the optimization of therapeutic peptides and contribute to the evolution of a world-class synthetic engine.

Key Responsibilities

: Drive Discovery: Lead peptide drug discovery campaigns from initial hit identification through to IND-enabling studies Innovate Synthetic Workflows: Onboard and optimize novel chemistries for high-throughput, automated peptide synthesis; troubleshoot complex synthetic challenges to generate high-quality leads, and curate a custom library of building blocks Cross-Functional Partnership: Collaborate with biology, software, automation, assay, and pharmacology teams to ensure seamless execution of ML platform objectives and drug discovery milestones Mentorship and Management: Actively mentor junior scientists, fostering a culture of technical excellence, continuous learning, and collaborative innovation Manage external collaborations and CROs efficiently, including teams of chemists, DMPK scientists and formulation experts Position

Requirements

Nice To Have

: Experience with organic synthesis, including transition metal catalysis and synthesis of non-canonical amino acids, is highly desired Experience with automation, software, and data-science integration into chemistry workflows Ability to utilize AI-tools to improve efficiency of research and build programs for data analysis or synthesis Knowledgeable on the key principles of ML-design for peptide therapeutics Prior experience with peptide-specific computational tools for hit discovery, SAR prioritization, molecular modeling, and physicochemical characterization The estimated base salary range for this role is $135,000 - $145,000.

Qualifications

This position is also eligible for two annual cash bonuses.

Scientist, Peptide Chemistry