Senior Research Associate, Translational

COMPANY DESCRIPTION Mirai Bio is a privately-held, Flagship-founded biotechnology company that is delivering genetic medicines from promise to performance. Mirai was built to solve one of the field’s central challenges: achieving precise, scalable delivery of diverse nucleic acid payloads to specific cells and tissues, particularly beyond the liver. By combining a large and growing proprietary in vivo biodistribution dataset, machine learning-guided lipid nanoparticle optimization, modular targeted particle design, and integrated translation and manufacturing capabilities, Mirai helps partners accelerate development, reduce technical risk, and pursue high-value programs making delivery a strategic advantage.

We are seeking collaborative, relentless problem solvers that share our passion for defining the future of genetic medicines together. THE ROLE The Senior Research Associate will be part of the Platform Group at Mirai and will support laboratory research activities towards development of novel technologies enabling next generation genomic medicines. The successful candidate will have a strong understanding of the technical and equipment needs in a lab as well as significant hands-on experience with standard and cell culturing and in vitro cell biology techniques.

They will work independently and as part of a collaborative team.

KEY RESPONSIBILITIES

Independently perform experiments related to in vivo and in vitro LNP using lab techniques that include flow cytometry, mammalian cell culture, mouse and NHP sample processing, cell isolation, ELISAs, plate-based reporter assays, cell killing assays, transfection, and protein binding assays Develop new in vitro bio-assays or optimize existing ones based on in-depth knowledge of laboratory techniques Analyze and accurately document assay results in an electronic lab notebook or other technical reporting formats PROFESSIONAL EXPERIENCE

QUALIFICATIONS

S. S. ) of relevant experience Previous experience with immune cell isolation and flow cytometry characterization is required Comfort with handling and processing NHP Mouse tissue samples Strong primary and cell line culture experience, including experience executing protocols, troubleshooting assays, and carrying out literature searches for method evaluation and refinement Knowledge of immunology, experience working with LNPs, and familiarity with performing BLI on octet instruments is a plus Proven ability to work independently and cross-functionally with highly skilled teams in a fast-paced, entrepreneurial, and technical environment Strong organizational and problem-solving skills Motivated, curious, and comfortable working with highly technical projects and personnel Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner Comfortable delivering against challenging commitments WHAT WE VALUE Scientific rigor and attention to data quality and reproducibility Curiosity and a problem-solving mindset Ability to work both independently and collaboratively in a fast-paced environment Clear and concise communication across disciplines Ownership and accountability in driving projects forward LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING: Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond.

Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.