Sr. Manager, Clinical Trial Lead - South San Francisco or Princeton, NJ

About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. , Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else.

We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit.

Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day.

Sr. Manager, Clinical Trial Lead Kardigan is seeking a Sr. Manager, Clinical Trial Lead to manage one of its cardiovascular clinical studies.

As a Clinical Trial Lead (CTL), you will be part of the Clinical Operations team reporting to the asset’s Clinical Operations Program Leader (COPL). The CTL may lead trials at a global level (overseeing multi-regional execution) or at a regional level (driving operational delivery in assigned countries/territories), depending on business needs. This role is for a regional CTL.

As a regional CTL, you will ensure that key project deliverables are met according to the budget and timelines and quality standards (as defined by regulations, SOPs, and ICH-GCP) with the overall goal of developing new and innovative treatments for cardiovascular diseases with unmet need. This position is 4-day onsite position in Princeton, NJ.

Key Responsibilities

: Trial Leadership Oversight Lead the planning, execution, and delivery of assigned clinical trials (global or regional scope). Drive study timelines, milestones, and deliverables from synopsis through Clinical Study Report. Serve as the primary operational point of contact for the cross-functional study team.

Align team execution with the study’s regulatory submission strategy and overall development plan. Study Start-Up Execution Oversee site feasibility, selection, initiation, and activation; delegate to Clinical Trial Managers (CTMs) as appropriate. Partner with CTMs to ensure vendor and site readiness across start-up, enrollment, monitoring, and closeout.

In partnership with the COPL, develop and execute participant recruitment strategies; review and approve operational plans, study manuals, and charters. Lead operational strategy related to drug supply, remote monitoring, and decentralized trial processes. Collaborate closely with the Clinical Development Lead on protocol development, amendments, and master ICFs.

Liaise with cross-functional team representatives to ensure cohesive trial execution. Vendor Management Provide input into CRO and vendor selection, ensuring alignment with trial needs and operational strategy. Direct and manage CRO and vendor partnerships, holding them accountable for timelines, quality, and budget commitments.