About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. , Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else.

We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit.

Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day.

Job Title: Executive Director, Portfolio Strategy Department: Portfolio Strategy Location: Chicago (preferred), South San Francisco, CA, Princeton, NJ - On-site 4 days per week (Mon to Thurs) Reports to: Chief Strategy Officer DESCRIPTION The Executive Director, Portfolio Strategy will play a key role in enabling data-driven, cross-functional decision-making on Kardigan’s investments in development programs and evaluation of trade-offs across the development pipeline. This individual will partner with Global Program Heads and the broader Program Teams to develop and maintain forward-looking decision frameworks, ensuring clarity on decision scope, trade-offs, and associated risks. They will conduct and oversee development of decision support analytics, such as eNPV analyses.

They will drive and facilitate portfolio decision forums, including agenda setting, preparation of supporting materials, and communication of outcomes. The Executive Director will collaborate closely with Finance to develop and maintain dynamic budgets at both the asset and portfolio levels, enabling scenario planning and prioritization aligned with the company’s strategic goals. This role will also lead the semi-annual portfolio planning cycle and support the preparation of materials for executive and Board-level discussions.

Responsibilities

, the Executive Director will be responsible for building and refining the operational infrastructure that supports portfolio governance, including development of scalable processes, templates, and tools. They will develop best practices, foster cross-functional alignment, and ensure that portfolio decisions are informed by integrated business and scientific perspectives. The ideal candidate is a strategic thinker with strong analytical and communication skills, proven leadership in cross-functional settings, and the ability to operate with clarity in a fast-paced, evolving environment.

Lead development and continuous refinement of the company’s portfolio strategy across clinical and preclinical assets. Establish objective, data-driven prioritization frameworks (NPV, probability-adjusted risk modeling, scenario planning).