About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. , Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else.

We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit.

Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day.

Position Title: Environmental Health and Safety (EHS) Manager Department: Facilities Reports To: Executive Director, Real Estate Facilities Location: South San Francisco, CA – On-site 4 days per week (Mon to Thurs) Job Overview As Kardigan grows our laboratory, clinical operations, and office footprint, we are hiring an experienced Environmental Health and Safety (EHS) professional to build and mature our EHS program. Reporting to the Executive Director, Real Estate Facilities, this role will focus on building on that foundation—operationalizing, scaling, and continuously improving EHS programs as the company grows. This is a hands-on role for a leader who can translate established frameworks into effective day-to-day execution across a dynamic R D environment.

Responsibilities

Model a pragmatic, solutions-oriented approach to safety—balancing speed and scientific progress with risk awareness; enabling teams to “do the work safely” rather than acting as a gatekeeper. Develop, implement, and continuously improve Kardigan's EHS program across our South San Francisco and Princeton sites, with an emphasis on laboratory and biotech R D operations. Serve as Kardigan's subject matter expert on environmental, health, biosafety, and chemical hygiene matters, advising scientific and operational leadership.

Develop and maintain a Chemical Hygiene Plan, Biosafety Manual, Hazard Communication Program, Injury and Illness Prevention Program (IIPP), and other Cal/OSHA and federal OSHA-required written programs. Lead biosafety oversight for BSL-1 and BSL-2 work, including risk assessments, SOP review, biological agent registrations, and support for any future activities.

Requirements

for biological and chemical materials. Oversee laboratory safety programs including chemical inventory management, fume hood and biosafety cabinet certifications, compressed gas and cryogen safety, and controlled substance compliance where applicable. Lead incident reporting, investigation, and incident learning process; track corrective and preventive actions and report metrics to leadership.