About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve. , Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients. At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else.

We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit.

Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries. These values are the foundation of our work, empowering us to make a real difference, every day.

Job Overview Kardigan is seeking a Director, External Manufacturing, to support development of a large late phase portfolio. This role will report directly to the Sr. Director of External Manufacturing.

In this role, you will be responsible for management and oversight of Kardigan’s network of Contract Development Manufacturing Organizations (CDMOs) for API and DP manufacturing for Kardigan’s portfolio of assets across its cardiovascular pipeline. You will ensure the seamless production scheduling, distribution, and logistics of APIs and DPs to support clinical and commercial programs by fostering strong partnerships with external manufacturers to meet corporate objectives.

Responsibilities

include contracts negotiation life cycle management within Tech Ops, CDMO project management, performance and business relationship management. This role requires collaboration with the Development, Quality, Analytical, Regulatory, and Supply Chain organizations at Kardigan. This is a 4-day, onsite position, based in South San Francisco, CA.

: Develop and implement comprehensive strategies for external manufacturing, ensuring alignment with the company’s clinical and commercial goals Support the selection, qualification, and management of CDMOs for API and DP manufacturing, ensuring robust supply chain continuity Collaborate closely with CMC technical leads to manage end-to-end external manufacturing operations, including technology transfer, process validation, production planning, and timely delivery of APIs and DPs Ensure efficient distribution and logistics guaranteeing safe, compliant and timely delivery of APIs and DPs Establish and maintain strong relationships with CDMOs, conducting regular business reviews to monitor performance, compliance, and continuous improvement initiatives Negotiate contracts and manage budgets associated with external manufacturing and logistics services Manage the tactical manufacturing strategy, execution of the business with CDMO organizations, and management of vendor performance.