COMPANY DESCRIPTION Expedition Medicines is a privately held, early-stage biotechnology company pioneering the emerging field of Protein Editing. At Expedition Medicines we create small molecules that edit protein structure and function to unlock presently undruggable targets and a broad array of therapeutic modalities. Our platform integrates novel small molecule chemistry and chemoproteomic discovery technologies with Machine Learning (ML) to enable generative design.

Expedition Medicines is backed by Flagship Pioneering, bringing their courage, vision, and resources to guide Expedition Medicines from platform validation to patient impact. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us! THE ROLE Expedition is seeking a motivated and innovative Senior Scientist, Proteomics to join our team.

In this role, you will play a critical role in the development and application of cutting-edge chemoproteomics workflows to support drug discovery programs and platform innovation. The successful candidate will combine strong experimental expertise in mass spectrometry-based proteomics with quantitative data analysis skills to enable biological insight and drive decision-making across multidisciplinary discovery teams. This individual will contribute to the advancement of a state-of-the-art chemical proteomics platform supporting targeted chemoproteomics, lead compound characterization, and biomarker discovery efforts.

The ideal candidate is highly collaborative, scientifically rigorous, and capable of independently driving projects in a fast-paced research environment.

KEY RESPONSIBILITIES

Operate, maintain, and troubleshoot state-of-the-art LC-MS instrumentation, including Orbitrap Tribrid platforms with FAIMS Develop, optimize, and execute targeted chemoproteomics workflows to support discovery programs Design and improve scalable sample preparation and experimental workflows for high-throughput proteomics applications Analyze and interpret large-scale proteomics datasets using quantitative and statistical approaches Collaborate closely with proteomics, biology, chemistry, and computational teams to design experiments, interpret results, and guide project strategy Develop and implement innovative chemical proteomics technologies and methodologies to enhance platform capabilities Communicate findings and technical advances clearly across cross-functional teams PROFESSIONAL EXPERIENCE

QUALIFICATIONS

D. S. g.

, Hamilton, Agilent Bravo) is a plus Excellent communication and cross-functional collaboration skills Demonstrated ability to work independently and manage multiple priorities in a fast-paced environment LOCATION: Cambridge, MA ABOUT FLAGSHIP PIONEERING Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies.