Calyxo, Inc. is a medical device company headquartered in Pleasanton, California, USA. The company was founded in 2016 to address the profound need for improved kidney stone treatment.

Kidney stone disease is a common, painful condition that consumes vast amounts of healthcare resources each year. Our team is led by executives and investors with a proven track record of commercializing paradigm-shifting devices to meet unmet needs within urology. Are you ready to change the future of kidney stone treatment?

We are seeking high achievers who want to be part of a dynamic team working in a fun, diverse atmosphere. Summary: We are seeking a highly skilled and innovative hardware engineer to lead development of advanced fluidic subsystems in kidney stone treatment. This role focuses on the design and control of irrigation and aspiration systems, combining pumps, valves, sensors, tubing sets, and embedded software into safe and reliable products.

This is a hands ‑ on technical leadership role for an engineer who enjoys developing both hardware and control algorithms, working across mechanical, electrical, and software boundaries to deliver clinically robust performance.

Requirements

, while aligning with strategic business objectives. In This Role, You Will : Own and architect end-to-end fluid control systems across capital equipment and disposable instruments/tubing sets. Define and drive development of control algorithms to regulate irrigation and aspiration under varying clinical and patient conditions.

for flow, pressure, responsiveness, alarms, and fault detection. Perform system modeling, trade studies, prototyping and bench testing to educate key component selection (pumps, sensors, actuators), validate decisions and de-risk technical challenges. Individually contribute to mechanical/electromechanical design for critical fluidics subsystem components and assemblies and provide expert design review of other team-members designs.

Lead cross-functional alignment across internal teams and external partners to ensure architectural integrity, V V readiness, and production scalability. Collaborate with Systems Test Engineering to drive design verification test planning and execution for fluid control hardware subsystems. , FMEA).

Organize system/sub-system-level technical design reviews to ensure coherent design across hardware, firmware and software interfaces. Collaborate with suppliers and internal operations representatives to perform root cause investigation, component lifecycle management and continuous improvement. Provide deep subject matter expertise toward the technology roadmap for fluidics and controls and related research endeavors.

Partner closely with mechanical, electrical, software, systems, clinical, quality, regulatory and other cross-functional teams to bring prototypes to the market. Mentor junior and non-specialist engineering talent, promoting a collaborative and high-performance work environment.

: Bachelor’s degree in Mechanical Engineering, Biomedical Engineering, Electrical Engineering, Mechatronics, or a related discipline. Master’s or PhD in a relevant engineering discipline preferred. 15+ years of experience developing fluidic, mechatronic, or control systems in a regulated product environment.

Experience with owning end-to-end hardware system architectures for fluidic control systems. Preferred familiarity with disposable fluidic component design and reusable/disposable system interfaces. Proven experience developing and tuning closed ‑ loop control systems for electromechanical hardware.

Preferred experience with irrigation and aspiration systems, endoscopic or urological devices, or surgical fluid management platforms.

Principal Hardware Engineer - Fluidics - Pleasanton, CA