Senior Research Scientist, High Throughput Biology

About Integrated Biosciences At Integrated, we are focused on advancing small molecule therapeutics for age-related diseases by leveraging our first-of-its-kind discovery platform at the intersection of phenotypic models of aging, chemistry, and AI. Backed by top-tier tech VCs, and with recent publications in Cell (2025), Nature (2024), Nature Aging (2023), and Nature Protocols (2025), we’re rapidly expanding our scientific team to accelerate our growing pipeline. We are seeking a talented Senior Scientist to drive our high throughput biology efforts and help us find the next generation of small molecule therapeutics in aging.

About The Role

We’re seeking a driven and highly skilled Senior Scientist to build and execute on our high throughput biology capabilities. In this role, you will be the in-house expert on high throughput assay development and execution — designing and running biochemical and cell-based assays in 384-well format, designing and deploying liquid handling automation and robotics, and turning large compound screening datasets into clear, actionable scientific insights. You’ll partner closely with the rest of our biology team along with medicinal chemistry to enable every stage of small molecule discovery from primary screening through hit-to-lead and lead optimization and you’ll play a central role in shaping how we run our screening platform as the company scales.

If you’re someone who loves the challenge of making an assay work at scale and is energized by generating and analyzing large high-quality data sets, we want to hear from you. You will Assay Development Screening Design, develop, miniaturize, and validate biochemical and cell-based assays in 384-well and higher-density formats to support primary screening, counterscreening, and selectivity profiling. Execute high throughput screening (HTS) campaigns against compound libraries and follow-up dose-response studies to characterize hit compounds and support hit-to-lead progression.

Develop and optimize assays to support lead optimization cycles, including potency, selectivity, mechanism of action, and relevant cellular endpoints tied to aging biology. Apply rigorous assay development principles (Z’ factor, signal-to-background, coefficient of variation) to ensure robust, reproducible, and HTS-ready assay performance. Identify, troubleshoot, and resolve assay performance issues; continuously improve throughput and data quality across the screening platform while looking for cost savings.

Lab Automation Platform Operations Operate, program, and maintain liquid handling and automation equipment including the Echo 650, Bravo, and integrated robotic workstations. Develop and optimize automation protocols for compound dispensing, reagent addition, plate washing, and detection to maximize throughput and minimize variability. Manage compound libraries and plate maps; coordinate with chemistry to ensure accurate compound tracking, dilution series, and QC for screening campaigns.

Data Analysis Write and maintain Python scripts and pipelines to process, analyze, visualize, and report large-scale screening datasets, including hit identification and dose-response curve fitting. Maintain accurate and well-documented ELN records for all screening experiments and present to cross-functional teams and leadership. You’re a good fit if you have (required) PhD in biology, biochemistry, chemical biology, or a closely related field.

3–5 years of industry experience in a drug discovery setting, with a primary focus on high throughput biology, assay development, or screening sciences. Demonstrated expertise in developing and running biochemical and cell-based assays in 384-well plate format for HTS and hit-to-lead. Hands-on experience operating and programming lab automation equipment, including acoustic dispensers (Echo 650), automated deck-based systems (Bravo), and integrated robotic liquid handling platforms.