Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. S.

FDA; IM-1021, a clinical-stage ROR1 ADC; IM-3050, an IND-cleared FAP-targeted radiotherapy; and IM-1617, an IND-cleared solid tumor ADC. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets. Position Overview The Executive Director, Early-Stage Program Team Leader provides enterprise-level leadership for three or more strategically critical early-stage development programs spanning preclinical through early clinical development (Phase I/II).

This role is accountable for defining and driving integrated program strategy, ensuring alignment with corporate objectives, portfolio priorities, and long-term value creation. This person will serve as the strategic and operational leader of cross-functional program teams, with authority to drive decisions, manage trade-offs, and escalate key investment considerations to executive governance forums. They will partner closely with senior functional leaders across Research, Clinical Development, CMC, Regulatory, and Commercial to ensure cohesive execution and disciplined portfolio advancement.

This role represents the program(s) at executive leadership reviews and plays a key role in shaping portfolio strategy, resource allocation, and development prioritization.

Responsibilities

Enterprise Program Strategy Portfolio Leadership Define and drive integrated, end-to-end program strategy across preclinical and early clinical development. Ensure alignment of program objectives with corporate strategy, long-range portfolio planning, and value inflection milestones. Shape development scenarios, investment cases, and risk-adjusted plans to support portfolio prioritization decisions.

Represent the program(s) in executive governance forums, providing strategic recommendations and clear decision frameworks. Contribute to broader portfolio strategy discussions, including sequencing, resource allocation, and capital deployment trade-offs. Cross-Functional Executive Leadership Lead senior cross-functional leaders in the development and execution of integrated program plans.

Drive alignment across R D, Clinical, CMC, Regulatory, Commercial, and other key stakeholders to ensure coordinated execution. Establish clear accountability, decision rights, and governance structures within the program team. Foster a high-performance team culture emphasizing transparency, urgency, and scientific rigor.

Mentor and influence senior leaders within and beyond the program team. Integrated Development Planning Execution Oversee development of integrated program plans, budgets, and long-range forecasts. Ensure robust transition of programs from discovery through IND and into early clinical development.

Guide early clinical strategy, including key design considerations that optimize probability of technical and regulatory success. Drive scenario planning to proactively address potential inflection points and development risks. Maintain accountability for program timelines, scope, and financial stewardship.

Executive Stakeholder Engagement Serve as the primary program representative to executive leadership and, as appropriate , to Board-level discussions. Present program strategy, data, risks, and value drivers in executive forums. Partner with Business Development on external collaborations, due diligence, and alliance strategy when applicable.

Interface with external stakeholders, including CROs, academic collaborators, and strategic partners.