About Arc Institute Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco. Unlike academia, our scientists have long-term funding and industry-like resources.

Unlike industry, they're free to pursue high-risk, long-term research without commercial pressures. Arc's Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone. Our two Institute Initiatives reflect this model in action: Virtual Cell Initiative : Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets, accelerating the path from biological insight to clinical trials.

Alzheimer's Disease Initiative : Mapping the genes, pathways, and environmental factors behind Alzheimer's disease to develop drug candidates that address root causes. More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding. About the position The IT Operations Manager is a technical and operational leader responsible for the day-to-day reliability, performance, and scalability of Arc’s technology systems.

This role serves as a key escalation point for infrastructure issues and the helpdesk, and a hands-on operator across our core platforms. The ideal candidate brings deep systems expertise across on-premises and cloud infrastructure, a service-delivery mindset, and the ability to help drive the organization forward. This position is full-time onsite (5 days a week).

About you You love working in a technical environment that is constantly evolving, growing and pushing towards the betterment of scientific research. You have a strong technical foundation, want to always be learning and to help shape a strong operational support team. You align your team's work with organizational goals and contribute to broader IT strategy.

Requirements

Bachelor's degree in Computer Science, Information Technology, or a related field, or equivalent professional experience 10+ years of progressive IT infrastructure and systems administration experience in a technical operations or senior engineering role 2+ years of experience in managing di