Scientist, Bioinformatics

About Arc Institute Arc Institute is an independent nonprofit research organization at the interface of artificial intelligence and biology, working to accelerate scientific progress and understand the root causes of complex diseases. Founded in 2021 and based in Palo Alto, Arc partners with Stanford University, UC Berkeley, and UC San Francisco. Unlike academia, our scientists have long-term funding and industry-like resources.

Unlike industry, they're free to pursue high-risk, long-term research without commercial pressures. Arc's Technology Centers and Core Investigator labs work side by side, integrating experimental and computational biology under one roof to tackle problems neither could solve alone. Our two Institute Initiatives reflect this model in action: Virtual Cell Initiative : Building a full-stack virtual cell model to identify disease mechanisms and nominate drug targets, accelerating the path from biological insight to clinical trials.

Alzheimer's Disease Initiative : Mapping the genes, pathways, and environmental factors behind Alzheimer's disease to develop drug candidates that address root causes. More than 300 Arconauts work together at our Palo Alto headquarters, backed by substantial long-term philanthropic funding. Why this position could be the best job you’ve ever had Join a new type of research institute.

Work within an organization that combines the speed, focus, and technical execution of a startup with the intellectual depth and scientific rigor of a world-class academic research environment. Arc was built to remove many of the traditional constraints on ambitious science, enabling researchers and technologists to pursue bold, long-term questions with uncommon institutional support. Work at the frontier of computational biology.

As part of the Computational Technology Center, you will help develop, scale, and deploy bioinformatics methods across some of the most exciting areas in modern biology, including single-cell genomics, multi-omics, Perturb-seq, spatial transcriptomics, CRISPR screens, and imaging-based technologies. Your work will not be limited to one project or dataset; you will contribute to reusable computational capabilities that can accelerate many scientific programs across the institute. Make a direct impact on high-risk, high-reward science.

This role sits at the interface of computational method development, production-scale data analysis, and experimental discovery. You will help turn complex biological data into actionable insights for scientists studying fundamental mechanisms of human disease, including cancer, neurodegeneration, and immune dysfunction. Collaborate with exceptional scientists and technologists.

You will work closely with experimentalists, computational scientists, technology center teams, and Core Investigators across Arc and its partner institutions: Stanford, UCSF, and UC Berkeley. This is an opportunity to be part of a highly collaborative environment where bioinformatics is not a downstream service, but a central driver of discovery. Build systems that matter.

Beyond analyzing data, you will help create robust, tested, documented, and scalable pipelines that support production-level research. Your work will improve how data flows from sequencing instruments to biological interpretation, helping teams move faster while maintaining scientific rigor and reproducibility. Grow with an ambitious institute.

Arc is still early in its trajectory, which means this role offers unusual opportunities for ownership, influence, and career growth. You will help shape bioinformatics practices, computational standards, and cross-team workflows as the institute expands. Do science in a culture built for curiosity and collaboration.

Arc aims to create an environment where excellent science, technical rigor, generosity, and intellectual ambition reinforce one another.